Download RadeonSoftwareSlimmer with the name of RadeonSoftwareSlimmer_XXX_net48.zip.
Open the application and go to the Pre-Install tab.
Select your installer file by clicking Browse and then confirm by double-clicking Next.
After the extraction process, untick everything in the Packages tab apart from:
AMD Display Driver
AMD Settings (Required for Radeon Software)
These settings might be required for monitor sound:
AMD Audio CoProcessor Bus Driver
AMD Audio filter driver
AMD HDMI Audio driver
AMD High-Definition Audio Controller
AMD Streaming Audio Filter Driver
Untick everything in the Scheduled Tasks tab.
Untick everything in the Display Driver Components. If you are using Audio from your monitor, do not remove High Definition Audio Bus.
Click Modify Installer and Run Installer, and then continue with driver setup as usual.
Configure Radeon Software
Open Radeon Software by right-clicking on the desktop.
Accept the terms and click the Settings icon in the top-right.
Configure the following settings in the Graphics tab:
Wait for Vertical Refresh - Always Off
Texture Filtering Quality - Performance
Tessellation Mode - Override application settings
Maximum Tessellation Level - Off
Configure the following in the Display tab:
AMD FreeSync - It has the potential to increase input latency due to extra processing. Your mileage may vary as it has supposedly improved over time.
GPU Scaling - Off
Color Depth - Value that matches your monitor's specifications
Disable all settings in Hotkeys and Preferences tabs.
Configure your refresh rate and resolution by typing the following command in Win+R:
rundll32 display.dll,ShowAdapterSettings 0
Disable the residual AMD services and drivers. Typically the AMD Crash Defender and AMD External Events Utility (required for VRR) services.
Disable Multi-Plane Overlay (MPO)
Disabling Multi-plane Overlay (MPO) can fix some desktop applications flickering or stuttering, which may occur during video playback using hardware acceleration with browsers. Black screens may occur when alt-tabbing from games or applications to a browser that has a video on loop. Some desktop apps may flicker or stutter when resizing the window on some computers.
MPO can be disabled by running the following command in CMD (make sure you run CMD as administrator):